Enhanced Rewarding Properties of Morphine, but not Cocaine, in arrestin-2 Knock-Out Mice
نویسندگان
چکیده
Laura M. Bohn,1 Raul R. Gainetdinov,2 Tatyana D. Sotnikova,2 Ivan O. Medvedev,2 Robert J. Lefkowitz,3 Linda A. Dykstra,4 and Marc G. Caron2 1Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, Departments of 2Cell Biology and 3Biochemistry and Medicine, Duke University Medical Center, Howard Hughes Medical Institute Laboratories, Durham, North Carolina 27710, and 4University of North Carolina at Chapel Hill, Department of Psychology, Chapel Hill, North Carolina 27599
منابع مشابه
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled receptor (GPCR) family of proteins. GPCRs are known to undergo desensitization involving phosphorylation of the receptor and the subsequent binding of beta(arrestins), wh...
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Drugs of abuse, such as psychostimulants and opiates, are generally considered as exerting their locomotor and rewarding effects through an increased dopaminergic transmission in the nucleus accumbens. Noradrenergic transmission may also be implicated because most psychostimulants increase norepinephrine (NE) release, and numerous studies have indicated interactions between noradrenergic and do...
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Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance and sensitization to the rewarding effects of morphine. Methods: The rewarding effects of morphine and isoniazid were assessed using a Condi...
متن کاملDifferential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in vivo. We have shown previously that mice lacking (beta)arr2 experience enhanced morphine-induced analgesia and do not become tolerant to morphine as determined in the hot-plat...
متن کاملConditioned rewarding effects of morphine and methadone in mice pre-exposed to cocaine.
BACKGROUND Methadone is widely accepted as the most effective treatment of opioid dependence. However, clinical observations indicate that the medication is less effective in individuals abusing cocaine. Diminished therapeutic efficacy of methadone in cocaine users is intriguing, but its mechanism has not been studied. METHODS Here, the conditioned place preference (CPP) procedure was used to...
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تاریخ انتشار 2003